Bone Marrow Mesenchymal Stem Cells Transfected with Distal-Less Homeobox 2 Gene Promote Articular Cartilage Repair after Injury

To investigate the repair effect of distal-less homeobox 2 transfected bone marrow-derived mesenchymal stem cells on knee cartilage injury. 20 male New Zealand large eared rabbits aged 6 to 7 mo were selected and fed for 1 w undergo injury modeling surgery. Reverse transcription-polymerase chain reaction, western blot hematoxylin-eosin staining used detect these related indicators. Behavioral scores in each group was calculated. The Wakitani total score showed a very significant level improvement damage marrow groups (p<0.01). reaction results that after 4 8 intervention, messenger RNA levels significantly increased Western surgery, expression type I collagen, II collagen proteoglycan aggrecan proteins increased. injection simple could promote had best w, indicating gene regulate proliferation differentiation long period time.